While using Outlook 2010 a user would get an immediate Undeliverable message when sending to one specific address. The diagnostic information contained the code of:
#550 5.4.4 ROUTING.NoNextHop; unable to route ##
This may have been caused by the user clicking a mailto URL in someones mail signature. If the person’s mailto URL is set up incorrectly, it may have the email address composed incorrectly and not use SMTP.
To fix this issue it is not as easy as just deleting Outlook’s cached copy of that single address. It takes the removal off the entire auto complete address cache inventory to resolve the issue.
From the Start menu search box or Run…, type Outlook /cleanautocompletecache
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